Personalized type 2 diabetes treatment in primary care: insights using real world data
Martina Ambrož - Personalized type 2 diabetes treatment in primary care: insights using real world data.
This thesis examines personalized treatment for individuals with type 2 diabetes (T2D) in primary care. We studied glycated hemoglobin A1c (HbA1c) and systolic blood pressure (SBP) levels at the start of glucose- and blood pressure-lowering medication between 2007 and 2020. Surprisingly, no significant differences were found based on age or frailty, highlighting a lack of personalized treatment. Another study revealed more hypotension-related adverse events in older patients, those with polypharmacy, and lower SBP levels, emphasizing the need for tailored approaches. Sex differences in medication prescribing were identified, with females less likely to receive certain medications. Females with T2D also showed age-specific variations in LDL cholesterol levels, suggesting the need for sex-specific treatment recommendations. Additionally, patients' willingness to engage in different treatments varied, with only half open to all options. These findings underscore the importance of personalized approaches in T2D treatment, requiring attention in clinical practice and future research.
Fluorescence-guided imaging for resection margin evaluation in head and neck cancer patients using cetuximab-800CW: A quantitative dose-escalation study.
Floris Jan Voskuil, Steven Jakob de Jongh, Wouter Tjerk Rudolph Hooghiemstra, Matthijs David Linssen, Pieter Jan Steinkamp, Sebastiaan Antonius Hendrik Johannes de Visscher, Kees-Pieter Schepman, Sjoerd Geert Elias, Gert-Jan Meersma, Pascal Klaas Christiaan Jonker, Jan Johannes Doff, Annelies Jorritsma-Smit, Wouter Bastiaan Nagengast, Bert van der Vegt, Dominic James Robinson, Gooitzen Michell van Dam, Max Johannes Hendrikus Witjes
Theranostics 2020; 10(9): 3994-4005. doi:10.7150/thno.43227
Implementation and benchmarking of a novel analytical framework to clinically evaluate tumor-specific fluorescent tracers.
Koller M, Qiu SQ, Linssen MD, Jansen L, Kelder W, de Vries J, Kruithof I, Zhang GJ, Robinson DJ, Nagengast WB, Jorritsma-Smit A, van der Vegt B, van Dam GM. Nat Commun. 2018 Sep 18;9(1):3739. doi: 10.1038/s41467-018-05727-y. PubMed PMID: 30228269; PubMed Central PMCID: PMC6143516.
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